Regenerating the epigenome
نویسندگان
چکیده
منابع مشابه
Regenerating the epigenome.
The ability of some organisms to regenerate parts of their body has fascinated scientists for decades. The process of regeneration depends on the potential of certain cells to proliferate and contribute to the formation of new tissue. Organisms have evolved two strategies by which to achieve this: the maintenance of adult stem cells and the induction of stem-cell properties in differentiated ce...
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The eukaryotic genome is packaged into a highly ordered chromatin structure, with specific domains regulating the transcription patterns of local genes. Hathaway et al. now present a breakthrough technique in the artificial induction of chromatin marks and use this experimental model to test the properties of an induced heterochromatic domain.
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During aging, the mechanisms that normally maintain health and stress resistance strikingly decline, resulting in decrepitude, frailty, and ultimately death. Exactly when and how this decline occurs is unknown. Changes in transcriptional networks and chromatin state lie at the heart of age-dependent decline. These epigenomic changes are not only observed during aging but also profoundly affect ...
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The chroGPS package provides tools to generate intuitive maps to visualize the association between genetic elements, with emphasis on epigenetics. The approach is based on Multi-Dimensional Scaling. We provide several sensible distance metrics, and adjustment procedures to remove systematic biases typically observed when merging data obtained under different technologies or genetic backgrounds....
متن کاملEpigenetics of the epigenome.
Jeff is the Doris and Normal Giles Professor of Molecular Biology and Functional Genomics in the Department of Genetics at the University of Georgia. He is also a Georgia Research Alliance Eminent Scholar and department head in Genetics. His research has focused on plant genome structure and evolution for more than 30 years, particularly the involvement of transposable elements in the growth an...
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ژورنال
عنوان ژورنال: EMBO reports
سال: 2011
ISSN: 1469-221X,1469-3178
DOI: 10.1038/embor.2011.10